Resident Evil 6.
Douglas revealed he's interested in reprising the role in an interview with horror gaming site Hell Descent, stating, "Hell yeah! I know RE6 is in the works, so hopefully I'll get a chance to audition for it...or you guys could bug Capcom into casting me in it! ;-) I'm workin' it, baby!"
Douglas later stated he had no inside knowledge that an actual Resident Evil 6 is in development, and was just going on the assumption that Capcom would be developing it.
Bringing Wesker into RE6 would be a challenge, however, since the man was dropped into molten lava then shot by dual rocket launchers. Of course, RE6 could always be a prequel...