Already revealed by the studio is their desire to avoid a new player character echoing Commander Shephard. The design team certainly have a lore buffet to feast off for Mass Effect.
The galactic adventuring could go anywhere because of the rich universe of alien species and hostile conflicts. Perhaps the focus won't be on mankind as saviours this time?
“We're in early stages of designing a completely new Mass Effect game,” Casey Hudson. “What would you want to see in it?” What does seem to be gaining traction among fans is the freedom to choose our own race. Deeper relationships with our potential crew seems to be high on the 'do want' list as well.
A major question about the new Mass Effect is when will it be set? Will it be post-Reaper war?