Not only will the latest Fable have motion tech, but an in-game store with micro-transactions will likely make an appearance. It would offer items, but features haven't been nailed down yet.
While speaking at the BAFTA event last night, Molyneux described 2009 as "the most exciting year ever". The Lionhead and Microsoft Game Studios boss has become a major advocate of Project Natal, with his studio deeply invested in the technology.
Milo & Kate is Molyneux's big Natal project, which features a boy or girl that the player can interact with through Natal's motion-sensing. Fable III was announced only recently.
Source: GamesIndustry.biz