According to The Kartel:
What we have heard so far: The new project will feature not one, not two, but multiple playable characters (Resident Evil: Outbreak, anyone?). None of which seem to be current characters found in the long running series. If it does take place in Raccoon City, this title will have to be a prequel…unless some entity unknown to us decided to rebuild the city, oh boy. Of course, cold hard facts about the release and any other details are subject to Capcom making a formal announcement on this, so we’ll keep our ears peeled.
Of course, if it is a prequel, D.C. Douglas will get his wish to play Albert Wesker again.