Dead Space 3. Some of the major bullet points of features announced by the preview co-op gameplay, universal ammo, no online competitive multiplayer, and a cover system. The game will take place on an ice planet called Tau Volantis.
Dead Space 3 will also make the Unitologists a tactical threat, as they too will use cover while shooting at Isaac. As far as new necromorphs, there will be a massive thirty story tall necro-centipede called "the Nexus". Other new creatures include "fodder", "feeders" and a "snow beast". The feeders will be humans who haven't been infected by a swarm or a divider head but end up (out of necessity) eating necromorph flesh.
Dead Space 3 will, of course, feature zero-G locations, which the developers say is a staple of the series. However, the developers want to make Dead Space 3 less linear, with large environments to explore, with "unique beta missions", aka side missions.. The game will also switch to universal ammo and make ammo drops more plentiful.
If that weren't enough, players will be able to combine weapons, such as combining the plasma cutter and the ripper.
Dead Space 3 will be shown off at E3 2012, so Strategy Informer will be checking it out.