Destiny 2's Menagerie is a thing to behold. This six-player raid-ish activity delivers precisely the sort of gameplay experience that fans know and love, and awards players with plenty of cool stuff along the way. Chalice of Opulence Runes, however, need a bit of introduction.
Menagerie Runes are special modifiers that, in essence, dictate the sort of loot you'll get for getting through the Menagerie. Figuring out what they do and what sort of awards they bring is a small science in-and-of-itself, but thankfully, the community has leaped to our help.
Destiny 2 Chalice of Opulence Rune Combos
There is an astonishing number of possible - and viable - Rune combinations for you to set up in your very own Chalice of Opulence, but going into it blind-folded may result in unnecessary frustration, if you don't get something you like. Thankfully, Destiny 2 redditor JpDeathBlade has done the gargantuan task of figuring out and organising Runes in a handy Google Spreadsheet for everyone else to reference!
To say that this is an immense help would be a severe understatement. According to JpDeathBlade, the down-low is the following: the first rune dictates the general item type (armour or armament), the second controls the specific loot pool, and the third decides the Masterwork level. The specifics are fuzzy at best, but we've no doubt it's only a matter of time before the rest of the system is figured out as well.
With this in mind, all you need to do is for you to actually set out and get the Runes through playing special Menagerie bounties, or by using the Runefinder consumable found at Werner 99-40. Happy hunting!