The Resident Evil 2 Remake comes with a refreshed focus on puzzles as you take both Leon and Claire through Raccoon City.
It's likely that you'll have noticed safes lying around, in your attempt to evade being munched on by zombies, and finding their codes isn't always easy. One such safe, alongside its safe code, waits in the Treatment Pool Room that's found in the Sewers.
How to unlock the Resident Evil 2 Remake Treatment Pool Safe
The Treatment Pool Room safe is on a table that's near the very entrance to the room, on the opposite side.
If you look through the room, towards the north, you'll find a document that reveals the location of the Treatment Pool Room safe code. As it turns out, it waits on the side of the safe itself.
The Treatment Pool Room safe code is Left 2, Right 12, Left 8. What's inside the safe changes based on the character you're playing as. Leon gets a shotgun stock that increases reloading speed, while Claire gets a reinforced frame for the SLS 60, enabling it to fire more potent rounds.